Live attenuated vaccines are being used to control Bluetongue in many parts of the world. Concerns regarding safety of these vaccines lead to development of inactivated vaccine. During the present study, inactivation of Bluetongue virus (BTV) using BEI at 3mM was tried and found to be effective in degrading BTV RNA, but the inactivated virus has shown residual infectivity. BTV has a tendency to form aggregates, which might have prevented inactivation by BEI, which was circumvented by addition low concentrations (0.04%) of formaldehyde.
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